Siena and Iona meet with a lot on the line on Tuesday evening.

The two teams will also be playing in arguably the world's most famous arena -- Madison Square Garden.

The Gaels (2-0, 10-3) have one of the top offenses in the country, while the Saints (0-2, 5-7) have played very stingy defense through the 12 games.

Siena has won its last two games, but they are still in search of the first conference victory of the season. 

For Siena to win, the Saints will likely have to play their best game of the season and still that might not be enough.